oncolytic virus การใช้

• It was the first approval of an oncolytic virus in the West.
• :: See Coley's toxins and Oncolytic virus.
• Oncolytic viruses are viruses that preferably infect cancer cells.
• A further approach involves the use of immunotherapy, such as oncolytic viruses.
• In the 1940s-50s some of the earliest human clinical trials with oncolytic viruses were started.
• Pexa-Vec is an engineered oncolytic virus that selectively destroys cancer cells and induces tumor immune response.
• Novel oncolytic viruses in Jennerex pipeline are engineered through the Selective Oncolytic Vaccinia Engineering ( SOLVE ) platform.
• In 1996, the first approval was given in Europe for a clinical trial using the oncolytic virus HSV1716.
• The main focus of Genelux is oncolytic immunotherapy based on attenuated, genetically engineered oncolytic viruses as therapeutic agent.
• Another approach is to generate an immune response " in situ " in the patient using oncolytic viruses.
• However, some studies have shown that pre-immunity to oncolytic viruses doesn't cause a significant reduction in efficacy.
• The company's oncolytic virus product, called Cavatak, is currently in clinical trials in metastatic melanoma and other cancers.
• Vaccinia virus, a virus credited for the eradication of smallpox, is being developed as an oncolytic virus, e . g.
• The oncolytic virus specifically infects and kills tumor cells which leads to oncolysis, which is thought to trigger an anti-tumor immune response.
• Ltd is an Australian biotechnology company working in the field of oncolytic viruses, that is, viruses that preferentially infect and kill cancer cells.
• Another way to help oncolytic viruses reach cancer growths after intravenous injection, is to hide them inside macrophages ( a type of white blood cell ).
• Superior anticancer effects have been observed when oncolytic viruses are engineered to express ( or be co-administered with ) immunostimulatory molecules such as GM-CSF.
• It was the first oncolytic virus approved in the West; it was approved in the US in October 2015 and provisionally approved in Europe in December 2015.
• Since Semliki Forest virus naturally infects cells of the central nervous system it has been pre-clinically tested as an oncolytic virus against the severe brain tumour type glioblastoma.
• The first oncolytic virus approved by a national regulatory agency is genetically not modified ECHO-7 strain enterovirus RIGVIR, approved in Latvia in 2004 for treatment of skin melanoma.